Retractions of scientific papers have increased about tenfold during the past decade, with many studies crumbling in cases of high-profile research misconduct that ranges from plagiarism to image manipulation to outright data fabrication. When worries about somebody's work reach a critical point, it falls to a peer, supervisor, junior partner or uninvolved bystander to decide whether to keep mum or step up and blow the whistle. Doing the latter comes at significant risk, and the path is rarely simple. Some make their case and move on; others never give up. And in what seems to be a growing trend, anonymous watchdogs are airing their concerns through e-mail and public forums.The reason that the watchdogs have to be anonymous is because scientists are far less amenable to having their mistakes exposed than most people are capable of imagining and the secular priesthood reliably retaliates against those who pull back the curtain on the myth.